25
Formulating Compositions to Achieve
Enhanced Oral Bioavailability Through
Supersaturation
James C. DiNunzio, MS; Dave A. Miller, PhD; James W.
McGinity, PhD; and Robert O. Williams III, PhD; describe
the underlying mechanisms for solubility enhancement
from supersaturatable systems, as well as current
applications of solid dispersion systems for bioavailability
enhancement.
34
Transdermal Delivery of Various Molecules
In Vivo Using Alpha-tocopheryl Phosphate
Paul Gavin, PhD; Annike Griffey, Robert Gianello, PhD; et al
investigate whether alpha-tocopheryl phosphate’s ability to
enhance transdermal penetration also enables it to
transdermally deliver drugs of interest.
“Individually and collectively, these
results demonstrate that formulations
containing TPM are effective in
transporting a diverse range of drugs
Drug Delivery Technology October 2008 Vol 8 No 9
dermally and transdermally in
concentrations sufficient to result in a
therapeutic effect. Therefore, the TPM
delivery platform has significant
potential to expand the number and
types of drugs available for topical
application and transdermal delivery.”
p. 34
6
42
BIORODTM: Bioadhesive-Based Oral
System for Targeted Delivery
Avinash Nangia, PhD, explains how the bioadhesive rate-
controlled oral delivery system provides controlled and
customized release as well as retains the drug at its
preferred absorption site in the GIT over an extended
duration.
50 Proof of Electro-Osmotic Drug Delivery:
A Prejudiced Clinical Trial, Delivering
From Mouth to Nose
Nicholas A. Sceusa, PharmD, and Paul M. Ehrlich, MD,
present the results of an IRB-approved, GCP-compliant,
controlled human clinical trial submitted as proof-of-
concept that electro-osmotic delivery exists and can be
induced by the dosage form.
60
Pulmonary Drug Delivery: Technology,
Regulation & Testing
Mark Copley, MEng, reviews current inhalation technology,
the associated regulatory framework, and the test methods
specified by the regulatory bodies for approval: delivered
dose uniformity and aerodynamic particle size measurement.
68
Taste Optimization of a Model Oral
Spray Drug Product
Jeffrey H. Worthington, MBA; David A. Tisi, MS; Frank E.
Blondino, PhD; and Foyeke O. Opawale, PhD; review a
unique and successful staged approach for developing a
palatable oral spray for a model API.
